TICKLING THE TCR - SELECTIVE T-CELL FUNCTIONS STIMULATED BY ALTERED PEPTIDE LIGANDS

被引：389

作者：

EVAVOLD, BD

SLOANLANCASTER, J

ALLEN, PM

机构：

[1] Dept. of Pathology, Washington University School of Medicine, St. Louis

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 12期

关键词：

D O I：

10.1016/0167-5699(93)90200-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent observations of T-cell responses following T-cell receptor (TCR) interaction with altered peptide ligands bate highlighted the complexity of this signalling system. The indications are that the TCR responds to minor changes in ligand with gradations of T-cell activation and effector functions. Brian Evavold, joanne Sloan-Lancaster and Paul Allen review these studies and present a model in which partial T-cell activation and TCR antagonism are related events in a continuum of signalling through the TCR.

引用

页码：602 / 609

页数：8

共 60 条

[1] ALEXANDER J, 1993, J IMMUNOL, V150, P1
[2] IDENTIFICATION OF THE T-CELL AND IA CONTACT RESIDUES OF A T-CELL ANTIGENIC EPITOPE
ALLEN, PM
MATSUEDA, GR
EVANS, RJ
DUNBAR, JB
MARSHALL, GR
UNANUE, ER
[J]. NATURE, 1987, 327 (6124) : 713 - 715
[3] PEPTIDE CONTRIBUTES TO THE SPECIFICITY OF POSITIVE SELECTION OF CD8+ T-CELLS IN THE THYMUS
ASHTONRICKARDT, PG
VANKAER, L
SCHUMACHER, TNM
PLOEGH, HL
TONEGAWA, S
[J]. CELL, 1993, 73 (05) : 1041 - 1049
[4] THRESHOLD TOLERANCE IN H-2K(B)-SPECIFIC TCR TRANSGENIC MICE EXPRESSING MUTANT H-2K(B) - CONVERSION OF HELPER-INDEPENDENT TO HELPER-DEPENDENT CTL
AUPHAN, N
JEZOBREMOND, A
SCHONRICH, G
HAMMERLING, G
ARNOLD, B
MALISSEN, B
SCHMITTVERHULST, AM
[J]. INTERNATIONAL IMMUNOLOGY, 1992, 4 (12) : 1419 - 1428
[5] BINDING OF IMMUNOGENIC PEPTIDES TO IA HISTOCOMPATIBILITY MOLECULES
BABBITT, BP
ALLEN, PM
MATSUEDA, G
HABER, E
UNANUE, ER
[J]. NATURE, 1985, 317 (6035) : 359 - 361
[6] STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2
BJORKMAN, PJ
SAPER, MA
SAMRAOUI, B
BENNETT, WS
STROMINGER, JL
WILEY, DC
[J]. NATURE, 1987, 329 (6139) : 506 - 512
[7] 3-DIMENSIONAL STRUCTURE OF THE HUMAN CLASS-II HISTOCOMPATIBILITY ANTIGEN HLA-DR1
BROWN, JH
JARDETZKY, TS
GORGA, JC
STERN, LJ
URBAN, RG
STROMINGER, JL
WILEY, DC
[J]. NATURE, 1993, 364 (6432) : 33 - 39
[8] INTERACTION BETWEEN A PROCESSED OVALBUMIN PEPTIDE AND IA MOLECULES
BUUS, S
COLON, S
SMITH, C
FREED, JH
MILES, C
GREY, HM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (11) : 3968 - 3971
[9] RESIDUES OF THE VARIABLE REGION OF THE T-CELL-RECEPTOR BETA-CHAIN THAT INTERACT WITH S-AUREUS TOXIN SUPERANTIGENS
CHOI, YW
HERMAN, A
DIGIUSTO, D
WADE, T
MARRACK, P
KAPPLER, J
[J]. NATURE, 1990, 346 (6283) : 471 - 473
[10] THE COGNITIVE PARADIGM AND THE IMMUNOLOGICAL HOMUNCULUS
COHEN, IR
[J]. IMMUNOLOGY TODAY, 1992, 13 (12): : 490 - 494

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