HOW SOUND IS THE DOUBLE-BLIND DESIGN FOR EVALUATING PSYCHOTROPIC-DRUGS

被引：94

作者：

FISHER, S

GREENBERG, RP

机构：

[1] Department, of Psychiatry, State University of New York Health Science Center, Syracuse, NY, 13210

来源：

JOURNAL OF NERVOUS AND MENTAL DISEASE | 1993年 / 181卷 / 06期

关键词：

D O I：

10.1097/00005053-199306000-00002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sufficient data have accumulated to raise serious doubts about the integrity of the double-blind design that is presumed to shield psychotropic drug trials from bias and expectations. A major deficit in most drug trials has been the use of inert rather than active placebos. The deficiencies of the double-blind paradigm call for a questioning stance with respect to previous studies of psychotropic drug efficacy. Various possible ways of strengthening the double-blind paradigm are reviewed.

引用

页码：345 / 350

页数：6

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