INTERLEUKIN-4 ACTS AS A POTENT STIMULATOR FOR EXPRESSION OF MONOCYTE CHEMOATTRACTANT JE/MCP-1 IN MOUSE PERITONEAL-MACROPHAGES

被引：24

作者：

KIKUCHI, H ^{[1
]}

HANAZAWA, S ^{[1
]}

TAKESHITA, A ^{[1
]}

NAKADA, Y ^{[1
]}

YAMASHITA, Y ^{[1
]}

KITANO, S ^{[1
]}

机构：

[1] MEIKAI UNIV,SCH DENT,DEPT ORAL MICROBIOL,SAKADO,SAITAMA 35002,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 203卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.2219

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The recruitment of monocyte/macrophages to inflammatory sites is one of the important events in inflammatory reactions. We show herein that interleukin-4(IL-4) acts as a potent stimulator for expression of monocyte chemoattractant JE/MCP-1 in mouse peritoneal macrophages. IL-4 induced the JE/MCP-1 gene expression in dose and time dependent fashion. Run-on assay suggests that IL-4 stimulates the JE/MCP-1 gene expression at transcriptional level. Monocyte chemotactic activity was detected in culture medium of the cytokine-treated cells. The chemotactic activity in the culture supernatant was completely neutralized by anti-JE/MCP-1 antiserum. (C) 1994 Academic Press, Inc.

引用

页码：562 / 569

页数：8

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