LIPOPROTEIN (A) AND MICROVASCULAR DISEASE IN TYPE-1 (INSULIN-DEPENDENT) DIABETES

被引：52

作者：

WINOCOUR, PH

BHATNAGAR, D

ISHOLA, M

ARROL, S

DURRINGTON, PN

机构：

[1] University of Manchester, Departments of Medicine, Hope Hospital, Salford

[2] University of Manchester, Departments of Medicine, Manchester Royal Infirmary

来源：

DIABETIC MEDICINE | 1991年 / 8卷 / 10期

关键词：

LIPOPROTEIN (A); NEPHROPATHY; ALBUMINURIA; HDL-CHOLESTEROL; TYPE-1; DIABETES;

D O I：

10.1111/j.1464-5491.1991.tb01531.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The influence of albuminuria and proliferative retinopathy on concentrations of serum lipoprotein (a) was examined cross-sectionally in 90 Type 1 diabetic patients. Concentrations of lipoprotein (a) were less in those with normoalbuminuria (90 (8-882) (median (range)) U l-1) than in those with micro- or macro-albuminuria (137 (19-1722) U l-1, p < 0.05). The prevalence of patients whose lipoprotein (a) concentrations were greater than 200 U l-1 was also greater (45 % vs 24 %, p = 0.03) among patients with albuminuria, but no difference was found between the microalbuminuric and macroalbuminuric groups (53 and 41 %, respectively), or between those with or without proliferative retinopathy. The present finding that lipoprotein (a) concentrations may be increased at an early stage of diabetic renal disease may in part account for the excess ischaemic heart disease associated with diabetic nephropathy.

引用

页码：922 / 927

页数：6

共 49 条

[1]

Hanssen KF, Dahl-Jorgensen K., Lauritzen T., Feldt-Rasmussen B., Brinchmann-Hansen O., Deckert T., Diabetic control and microvascular complications: the near normoglycaemic experience, Diabetologia, 29, pp. 677-684, (1986)

[2]

Testa MA, Puklin JE, Sherwin RS, Simonson DC, Clinical predictors of retinopathy and its progression in patients with type 1 diabetes during CSII or conventional insulin treatment, Diabetes, 34, pp. 61-69, (1985)

[3]

Tchobroutsky G., Relation of diabetic control to development of microvascular complications, Diabetologia, 15, pp. 143-152, (1978)

[4]

Young RJ, MacIntyre CCA, Martyn CN, Prescott RJ, Ewing DJ, Smith AF, Et al., Progression of subclinical polyneuropathy in young patients with Type 1 (insulindependent) diabetes: association with glycaemic control and microangiopathy (microvascular complications), Diabetologia, 29, pp. 156-163, (1986)

[5]

Dornan TL, Carter RD, Bron AJ, Turner RC, Mann JI, Low density lipoprotein cholesterol: an association with the severity of diabetic retinopathy, Diabetologia, 22, pp. 167-170, (1982)

[6]

Moorhead JF, Chan MK, El-Nahas M., Varghese Z., Lipid nephrotoxicity in chronic progressive glomerular and tubulo‐interstitial disease, Lancet, 2, pp. 1309-1311, (1982)

[7]

Parving HH, Viberti GC, Keen H., Christiansen JS, Lassen NA, Haemodynamic factors in the genesis of diabetic micro‐angiopathy, Metabolism, 32, pp. 943-949, (1983)

[8]

MacRury SM, Lowe GDO, Blood rheology in diabetes mellitus, Diabetic Med, 7, pp. 285-291, (1990)

[9]

Colwell JA, Winocour PD, Halushka OV, Do platelets have anything to do with diabetic microvascular disease?, Diabetes, 32, pp. 14-19, (1983)

[10]

Lowe GDO, Lowe JM, Drummond MM, Reith S., Belch JJF, Kesson CM, Et al., Blood viscosity in young male diabetics with and without retinopathy, Diabetologia, 18, pp. 359-363, (1980)

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