TEMPERATURE-RELATED ABSORPTION AND EXCRETION OF OXOLINIC ACID IN RAINBOW-TROUT (ONCORHYNCHUS-MYKISS)

被引:53
作者
BJORKLUND, HV
ERIKSSON, A
BYLUND, G
机构
[1] Institute of Parasitology, Åbo Akademi University, rAbo
关键词
D O I
10.1016/0044-8486(92)90285-S
中图分类号
S9 [水产、渔业];
学科分类号
0908 ;
摘要
The absorption and elimination of oxolinic acid in serum, bile and tissues of rainbow trout were studied at 5, 10 and 15-degrees-C after a single oral dose of 75 mg/kg. The maximum levels of oxolinic acid were obtained in serum within 1, 4 and 6 days at 16, 10 and 5-degrees-C, respectively. The highest drug concentrations were measured in bile followed by liver, kidney, muscle tissue and serum. The higher levels of oxolinic acid in tissues compared to serum indicate a good distribution of the drug. The elimination half-life in serum was 24 h at 16-degrees-C, 4.0 days at 10-degrees-C and 6.1 days at 5-degrees-C. With the detection limit of 0.01-mu-g/g for the oxolinic acid HPLC assay, the predicted withdrawal time with 95% confidence for muscle tissue was 28 days at 16-degrees-C, 60 days at 10-degrees-C and 140 days at 5-degrees-C. Results obtained under laboratory conditions were in accordance with results from field trials.
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页码:17 / 27
页数:11
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