EXPRESSION OF FOCAL ADHESION KINASE GENE AND INVASIVE CANCER

被引：310

作者：

WEINER, TM

LIU, ET

CRAVEN, RJ

CANCE, WG

机构：

[1] UNIV N CAROLINA,SCH MED,DEPT SURG,3010 OLD CLIN BLDG,CB 7210,CHAPEL HILL,NC 27599

[2] UNIV N CAROLINA,SCH MED,DEPT MED,CHAPEL HILL,NC 27599

[3] UNIV N CAROLINA,SCH MED,LINEBERGER COMPREHENS CANC CTR,CHAPEL HILL,NC 27599

来源：

LANCET | 1993年 / 342卷 / 8878期

关键词：

D O I：

10.1016/0140-6736(93)92881-S

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The focal adhesion kinase (FAK) gene produces a tyrosine kinase that localises to contact points between cells and extracellular matrix. It is believed to be an important signal molecule in cell adhesion. We have isolated a human homologue of the FAK gene from primary sarcomas and looked for FAK mRNA in 49 human tissue samples, including paired normal and neoplastic samples. We found increased levels of FAK in 1 of 8 adenomatous tissues, in 17 of 20 invasive tumours, and in all 15 metastatic tumours. There was no detectable FAK mRNA in 6 normal tissue samples. These observations suggest that FAK overexpression may accompany changes in signal pathways involved in tumour cell invasion.

引用

页码：1024 / 1025

页数：2

共 10 条

[1] REGULATION OF FOCAL ADHESION-ASSOCIATED PROTEIN TYROSINE KINASE BY BOTH CELLULAR ADHESION AND ONCOGENIC TRANSFORMATION [J].