THE PRIMARY SEQUENCE OF MURINE CAVEOLIN REVEALS A CONSERVED CONSENSUS SITE FOR PHOSPHORYLATION BY PROTEIN-KINASE-C

被引：53

作者：

TANG, ZL ^{[1
]}

SCHERER, PE ^{[1
]}

LISANTI, MP ^{[1
]}

机构：

[1] WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142

来源：

GENE | 1994年 / 147卷 / 02期

关键词：

CAVEOLAE; V-SRC SUBSTRATE; CELL TRANSFORMATION; POTOCYTOSIS; SIGNALING;

D O I：

10.1016/0378-1119(94)90087-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report here the cloning of the murine cDNA encoding caveolin, a known v-Src substrate and caveolar marker protein. Interestingly, analysis of the murine cDNA and comparison with caveolin from other species reveals a previously unrecognized consensus site for protein kinase C (PKC) phosphorylation. This finding could have important implications as (i) both the morphology and function of caveolae are dramatically affected by PKC activators; and (ii) PKCalpha is concentrated in isolated caveolin-rich membrane domains. In addition, this first step should facilitate the use of the mouse as a genetic system for elucidating the role of caveolin in caveolar functioning.

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收藏

页码：299 / 300

页数：2

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