SIMULTANEOUS DETERMINATION OF IMIPRAMINE AND AMITRYPTILINE BY DERIVATIVE SPECTROPHOTOMETRY

被引：18

作者：

FRAGA, JMG ^{[1
]}

ABIZANDA, AIJ ^{[1
]}

MORENO, FJ ^{[1
]}

LEON, JJA ^{[1
]}

机构：

[1] UNIV LA LAGUNA, DEPT ANALYT CHEM BROMATOL & TOXICOL, E-38204 LA LAGUNA, SPAIN

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1991年 / 9卷 / 02期

关键词：

IMIPRAMINE; AMITRYPTILINE; TRICYCLIC ANTIDEPRESSANTS; DERIVATIVE SPECTROPHOTOMETRY; SIMULTANEOUS DETERMINATION;

D O I：

10.1016/0731-7085(91)80133-T

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Three methods are proposed for the simultaneous determination of imipramine and imitryptiline by derivative spectrophotometry, one of them using both first- and second-derivative spectra, and the others using the first- and second-derivative spectra, respectively, obtained from a "diode array" spectrophotometer. The methods allow the determination of 0.62-10.14-mu-g ml-1 of imipramine, and 0.63-10.04-mu-g ml-1 of amitryptiline, and have been applied to their determination in blood serum.

引用

页码：109 / 115

页数：7

共 17 条

[1]

BLAZSEKBODO A, 1982, FARMACIA, V30, P193

[2]

BOSCH F, 1988, CIENC IND FARM, V7, P144

[3] POTENTIOMETRIC TITRATION OF PHARMACEUTICAL COMPOUNDS IN FORMULATIONS WITH SODIUM TETRAPHENYLBORATE [J].

DIAMANDIS, EP ;

CHRISTOPOULOS, TK .

ANALYTICA CHIMICA ACTA, 1983, 152 (SEP) :281-284

[4]

DOREY RC, 1988, CLIN CHEM, V34, P2348

[5]

DRAPER NR, 1966, APPLIED REGRESSION A

[6]

FERNANDEZ P, 1988, ANAL LETT, V21, P1045

[7] A BAYESIAN-ANALYSIS OF THE LINEAR CALIBRATION-PROBLEM [J].

HUNTER, WG ;

LAMBOY, WF .

TECHNOMETRICS, 1981, 23 (04) :323-328

[8]

IBRAHIN ESA, 1985, TALANTA, V30, P531

[9]

LITTER M, 1975, FARMACOLOGIA

[10] DEVELOPMENT AND EVALUATION OF A RADIOIMMUNOASSAY FOR THE ANALYSIS OF BODY-FLUIDS TO DETERMINE THE PRESENCE OF TRICYCLIC ANTIDEPRESSANT DRUGS [J].

MASON, PA ;

ROWAN, KM ;

LAW, B ;

MOFFAT, AC ;

KILNER, EA ;

KING, LA .

ANALYST, 1984, 109 (09) :1213-1215

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