THE ACTIONS OF MELANIN-CONCENTRATING HORMONE (MCH) ON PASSIVE-AVOIDANCE IN RATS - A PRELIMINARY-STUDY

被引：27

作者：

MCBRIDE, RB

BECKWITH, BE

SWENSON, RR

SAWYER, TK

HADLEY, ME

MATSUNAGA, TO

HRUBY, VJ

机构：

[1] UNIV N DAKOTA,DEPT PSYCHOL,GRAND FORKS,ND 58202

[2] WARNER LAMBERT PARKE DAVIS,ANN ARBOR,MI 48105

[3] UNIV ARIZONA,DEPT ANAT,TUCSON,AZ 85721

[4] UNIV ARIZONA,DEPT CHEM,TUCSON,AZ 85721

来源：

PEPTIDES | 1994年 / 15卷 / 04期

关键词：

BEHAVIOR; EXTINCTION; LEARNING; MEMORY; MCH; MSH; NEUROPEPTIDES; PASSIVE AVOIDANCE;

D O I：

10.1016/0196-9781(94)90105-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Melanin-concentrating hormone (MCH) is a hepadecapeptide hormone that is synthesized in the CNS and is responsible for melanosome aggregation in the teleost fish. Recent evidence suggests that this peptide hormone has a unique distribution in the mammalian brain, which leads to the speculation that it may serve as a neuromodulator. The present study was undertaken to explore the comparative effects of MCH to those of alpha-melanocyte-stimulating Hormone (MSH) (a neuropeptide that is known to influence learning) on the rate of extinction of a passive avoidance response in rats. Both MCH and MSH were administered SC at 10 mu g per animal. Treatment with MCH appeared to hasten, whereas treatment with MSH appeared to delay, extinction of the passive avoidance response.

引用

页码：757 / 759

页数：3

共 17 条

[1] SALMONID MELANIN-CONCENTRATING HORMONE INHIBITS CORTICOTROPIN RELEASE
BAKER, BI
BIRD, DJ
BUCKINGHAM, JC
[J]. JOURNAL OF ENDOCRINOLOGY, 1985, 106 (02) : R5 - R8
[2] MELANIN CONCENTRATING HORMONE INHIBITS THE RELEASE OF ALPHA-MSH FROM TELEOST PITUITARY-GLANDS
BARBER, LD
BAKER, BI
PENNY, JC
EBERLE, AN
[J]. GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1987, 65 (01) : 79 - 86
[3] BEHAVIORAL-INFLUENCES OF THE NEUROPEPTIDES ACTH AND MSH - METHODOLOGICAL REVIEW
BECKWITH, BE
SANDMAN, CA
[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1978, 2 (04) : 311 - 338
[4] BECKWITH BE, 1988, PEPTIDE HORMONES EFF, P195
[5] Beckwith BE, 1988, MELANOTROPIC PEPTIDE, V2, P43
[6] EFFECTS OF ACTH-LIKE NEUROPEPTIDES ON ANIMAL BEHAVIOR AND MAN
BOHUS, B
[J]. PHARMACOLOGY, 1979, 18 (03) : 113 - 122
[7] EFFECTS OF ALPHA-MSH AND MELATONIN ON PASSIVE-AVOIDANCE AND ON PA-INDUCED DEFECATION AND PLASMA 11-OHCS IN HYPOPHYSECTOMIZED RATS
DATTA, PC
KING, MG
[J]. PEPTIDES, 1980, 1 (02) : 147 - 153
[8] EFFECTS OF MSH ON A RESTRICTED PASSIVE-AVOIDANCE RESPONSE
DEMPSEY, GL
KASTIN, AJ
SCHALLY, AV
[J]. HORMONES AND BEHAVIOR, 1972, 3 (04) : 333 - 337
[9] PEPTIDE-SYNTHESIS .9. SOLID-PHASE SYNTHESIS OF MELANIN CONCENTRATING HORMONE USING A CONTINUOUS-FLOW POLYAMIDE METHOD
EBERLE, AN
ATHERTON, E
DRYLAND, A
SHEPPARD, RC
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1986, (02): : 361 - 367
[10] DIFFERENTIAL STRUCTURAL REQUIREMENTS FOR THE MSH AND MCH ACTIVITIES OF MELANIN CONCENTRATING HORMONE
HADLEY, ME
ZECHEL, C
WILKES, BC
CASTRUCCI, AMD
VISCONTI, MA
POZOALONSO, M
HRUBY, VJ
[J]. LIFE SCIENCES, 1987, 40 (12) : 1139 - 1145

← 1 2 →