SOME COMPARISONS AMONG THE CALMING AND PAIN-RELIEVING EFFECTS OF SUCROSE, GLUCOSE, FRUCTOSE AND LACTOSE IN INFANT RATS

被引:80
作者
BLASS, EM
SHIDE, DJ
机构
[1] Department of Psychology, Cornell University, Ithaca, NY 14853, Uris Hall
关键词
D O I
10.1093/chemse/19.3.239
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Ultrasonic vocalizations were recorded from 10-day-old albino rats while they were isolated from their dam and siblings. Each rat received a 1.0% BW intra-oral infusion of sucrose, fructose, glucose or lactose at a concentration range of 0.22-0.66 M for 3 min and their vocalizations were determined during the infusion and for an additional 7 min. Sucrose, fructose and glucose all significantly reduced vocalizations to about 50% of baseline levels, whereas lactose, the milk sugar, was ineffective. Moreover, the dose-response function was flat for the three effective sugars. In a second experiment, the effects of these sugars on heat escape latency were measured. Sucrose, fructose and glucose each elevated the latency with which infant rats removed a paw from a 48 degrees C surface; lactose did not. These findings of lactose ineffectiveness and the flat dose-response function for the other three sugars exactly parallel those obtained for human newborns. Their implications are discussed.
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页码:239 / 249
页数:11
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