KIM127, an antibody that promotes adhesion, maps to a region of CD18 that includes cysteine-rich repeats

被引：48

作者：

Stephens, P

Romer, JT

Spitali, M

Shock, A

Ortlepp, S

Figdor, CG

Robinson, MK

机构：

[1] CELLTECH LTD,SLOUGH SL1 4EN,BERKS,ENGLAND

[2] UNIV NIJMEGEN HOSP,6525 EX NIJMEGEN,NETHERLANDS

来源：

CELL ADHESION AND COMMUNICATION | 1995年 / 3卷 / 05期

关键词：

adhesion; antibody; epitope mapping; integrin; leucocyte;

D O I：

10.3109/15419069509081292

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of fusion proteins have been generated between human and mouse CD18. These proteins have been used to carry out preliminary mapping studies on a number of anti-CD18 antibodies including KIM127 an antibody that promotes CD18-dependent adhesion. This antibody maps to a region of the CD18 molecule between amino acids 406 and 570 in a region containing cysteine-rich repeats.

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页码：375 / 384

页数：10

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