STRUCTURE-ACTIVITY-RELATIONSHIPS WITHIN A SERIES OF C(7)-SUBSTITUTED-OXYIMINOCEPHALOSPORINS CONTAINING THE C(3)-METHYLAMINOPYRIDINIUMTHIOMETHYL SUBSTITUENT - SYNTHESIS AND BIOLOGICAL PROPERTIES OF BRL-57342 AND SOME CLOSE ANALOGS

被引：3

作者：

ADAMS, RG ^{[1
]}

BRAIN, EG ^{[1
]}

BRANCH, CL ^{[1
]}

GUEST, AW ^{[1
]}

HARRINGTON, FP ^{[1
]}

MIZEN, L ^{[1
]}

NEALE, JE ^{[1
]}

PEARSON, MJ ^{[1
]}

SIMPSON, IN ^{[1
]}

SMULDERS, H ^{[1
]}

ZOMAYA, II ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DIV RES,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 05期

关键词：

D O I：

10.7164/antibiotics.48.417

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

(6R,7R)-7-[2-(2-Amino-4-thiazolyl)-2-[(Z)-[(S)-carboxy(3,4-dihydroxyphenyl)methyl]oxyimino]acetamido]-3-(1-methylaminopyridinium- 4-thiomethyl)ceph-3-em-4-carboxylate sodium salt (BRL 57342, 1f) combines excellent in vitro antibacterial potency against Gram-positive and Gram-negative bacteria, including P. aeruginosa and Acinetobacter spp., with excellent stability to extended spectrum beta-lactamases. This potency is reflected in in vivo efficacy studies.

引用

页码：417 / 424

页数：8

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