TOPOGRAPHIC STUDY OF HELICOBACTER-PYLORI AND HLA-DR ANTIGEN EXPRESSION ON GASTRIC EPITHELIUM

被引：20

作者：

CHIBA, M

ISHII, N

ISHIOKA, T

MURATA, M

MASAMUNE, O

SUGIYAMA, T

YACHI, A

机构：

[1] First Department of Internal Medicine, Akita University School of Medicine, Akita City, 010

[2] Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo City, 060, Nishi 17-chome, Minami 1-jo, Chuo-ku

来源：

JOURNAL OF GASTROENTEROLOGY | 1995年 / 30卷 / 02期

关键词：

HELICOBACTER PYLORI; HLA-DR ANTIGENS; GASTRIC EPITHELIUM; IMMUNOHISTOCHEMISTRY; LYMPH FOLLICLE;

D O I：

10.1007/BF02348658

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Helicobacter pylori and HLA-DR antigen expression on gastric epithelium, identified by an indirect immunoperoxidase staining method using monoclonal antibodies against H. pylori and HLA-DR antigens, were studied topographically. Fifty-nine biopsy specimens from 41 patients who had neither gastric cancer nor peptic ulcers were examined. H. pylori was observed predominantly over or on the surface epithelium, while HLA-DR antigens were frequently expressed on the epithelium of the isthmus region. These observations led to the conclusion that there was no direct topographic association between H. pylori and epithelial HLA-DR expression. However, the frequency of HLA-DR expression in H. pylori-positive (28/29) specimens was significantly higher than that in H. pylori-negative (18/30) specimens (P < 0.01). Furthermore, a greater number of H. pylori was associated with a stronger expression of HLA-DR antigens (P < 0.001). We conclude that H. pylori is indirectly related to HLA-DR expression on gastric epithelium. H. pylori is the first microbial agent that has been suggested to be associated with epithelial HLA-DR expression in the human gastrointestinal tract.

引用

页码：149 / 155

页数：7

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