FAILURE OF DRUG PENETRATION AND ACQUISITION OF DRUG-RESISTANCE IN CHRONIC TUBERCULOUS EMPYEMA

被引：66

作者：

ELLIOTT, AM

BERNING, SE

ISEMAN, MD

PELOQUIN, CA

机构：

[1] National Jewish Center for Immunology and Respiratory Medicine, Denver, CO

来源：

TUBERCLE AND LUNG DISEASE | 1995年 / 76卷 / 05期

关键词：

D O I：

10.1016/0962-8479(95)90016-0

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

We describe a patient with drug-resistant chronic tuberculous empyema in whom substantial differences between achievable pleural fluid and serum drug concentrations were displayed, The ratio of maximum concentration in pleural fluid to serum was especially low for rifampin (4%) but was also low for streptomycin (34%) and ofloxacin (48%). Subtherapeutic drug concentrations in the pleural fluid may have contributed to acquisition of drug resistance in this case.

引用

页码：463 / 467

页数：5

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