PERSISTENT BINDING OF BUTTER YELLOW METABOLITES TO RAT LIVER DNA

被引：72

作者：

WARWICK, GP

ROBERTS, JJ

机构：

来源：

NATURE | 1967年 / 213卷 / 5082期

关键词：

D O I：

10.1038/2131206a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Radioactive metabolites of butter yellow (3H-dimethyl aminoazo benzene) were found to bind covalently to the liver DNA of hooded rats. The specific concentration of radioactivity dropped to roughly a half its initial value in the 1st 7 days and then remained roughly constant for 3 months, which implies an absence of repair. This observation could explain chromosome aberration observed in regenerating liver after treatment with carcinogens and may play a part in the latent period in the carcinogenic process.

引用

页码：1206 / +

页数：1

共 10 条

[1]

BUCHER NLR, 1951, CANCER RES, V11, P457

[2] CHROMOSOME ABERRATIONS IN LIVER CELLS IN RELATION TO SOMATIC MUTATION THEORY OF AGING [J].