THE PROTECTIVE AND CURATIVE ACTION OF WITHANIA-FRUTESCENS LEAF EXTRACT AGAINST CCL4-INDUCED HEPATOTOXICITY

被引：26

作者：

MONTILLA, MP

CABO, J

NAVARRO, MC

RISCO, S

JIMENEZ, J

ANEIROS, J

机构：

[1] UNIV GRANADA,FAC PHARM,DEPT PHARMACOL,E-18071 GRANADA,SPAIN

[2] UNIV GRANADA,FAC MED,DEPT PATHOL,E-18071 GRANADA,SPAIN

来源：

PHYTOTHERAPY RESEARCH | 1990年 / 4卷 / 06期

关键词：

WITHANIA-FRUTESCENS; CARBON TETRACHLORIDE; HEPATIC PROTECTION;

D O I：

10.1002/ptr.2650040603

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We studied the protective and curative action of an ethanol extract of Withania frutescens leaves against CCl4-induced hepatotoxicity. Hepatoprotective activity was evaluated in terms of the LD50 of CCl4, the modification of Nembutal-induced sleep, the action on bile flow, serum transaminase and hepatic fatty acids levels and a histopathological study of liver tissue. Curative action was assessed by measuring the duration of Nembutal-induced sleep and with a histopathological study of liver tisue. The findings indicate that the leaf extract has both preventative and curative activity against CCl4-induced liver damage.

引用

页码：212 / 215

页数：4

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