INTERLEUKIN-1 RECEPTOR ANTAGONIST ACTIVITY OF A HUMAN INTERLEUKIN-1 INHIBITOR

被引：1114

作者：

HANNUM, CH

WILCOX, CJ

AREND, WP

JOSLIN, FG

DRIPPS, DJ

HEIMDAL, PL

ARMES, LG

SOMMER, A

EISENBERG, SP

THOMPSON, RC

机构：

[1] SYNERGEN INC,1885 33RD ST,BOULDER,CO 80301

[2] UNIV COLORADO,HLTH SCI CTR,DEPT MED,DIV RHEUMATOL,DENVER,CO 80262

来源：

NATURE | 1990年 / 343卷 / 6256期

关键词：

D O I：

10.1038/343336a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations, and is therefore a pure receptor antagonist. © 1990 Nature Publishing Group.

引用

页码：336 / 340

页数：5

共 15 条

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