TOWARD COMPUTER-AIDED SITE-DIRECTED MUTAGENESIS OF ENZYMES

被引:72
作者
WARSHEL, A
SUSSMAN, F
机构
关键词
D O I
10.1073/pnas.83.11.3806
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
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页码:3806 / 3810
页数:5
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共 19 条
[1]  
[Anonymous], MODERN THEORETICAL C
[2]   ROLE OF A BURIED ACID GROUP IN MECHANISM OF ACTION OF CHYMOTRYPSIN [J].
BLOW, DM ;
BIRKTOFT, JJ ;
HARTLEY, BS .
NATURE, 1969, 221 (5178) :337-&
[3]   REDESIGNING TRYPSIN - ALTERATION OF SUBSTRATE-SPECIFICITY [J].
CRAIK, CS ;
LARGMAN, C ;
FLETCHER, T ;
ROCZNIAK, S ;
BARR, PJ ;
FLETTERICK, R ;
RUTTER, WJ .
SCIENCE, 1985, 228 (4697) :291-297
[4]   OLIGONUCLEOTIDE-DIRECTED MUTAGENESIS AS A GENERAL AND POWERFUL METHOD FOR STUDIES OF PROTEIN FUNCTION [J].
DALBADIEMCFARLAND, G ;
COHEN, LW ;
RIGGS, AD ;
MORIN, C ;
ITAKURA, K ;
RICHARDS, JH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (21) :6409-6413
[5]   STRUCTURAL BASIS OF ACTIVATION AND ACTION OF TRYPSIN [J].
HUBER, R ;
BODE, W .
ACCOUNTS OF CHEMICAL RESEARCH, 1978, 11 (03) :114-122
[6]  
HUBER R, 1974, J MOL BIOL, V89, P73, DOI 10.1016/0022-2836(74)90163-6
[7]   COMPARISON OF EXPERIMENTAL BINDING DATA AND THEORETICAL MODELS IN PROTEINS CONTAINING SUBUNITS [J].
KOSHLAND, DE ;
NEMETHY, G ;
FILMER, D .
BIOCHEMISTRY, 1966, 5 (01) :365-+
[8]   SERINE PROTEASES - STRUCTURE AND MECHANISM OF CATALYSIS [J].
KRAUT, J .
ANNUAL REVIEW OF BIOCHEMISTRY, 1977, 46 :331-358
[9]   PROTEIN CONFORMATION, DYNAMICS, AND FOLDING BY COMPUTER-SIMULATION [J].
LEVITT, M .
ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING, 1982, 11 :251-271
[10]   DIRECTED MUTAGENESIS OF DIHYDROFOLATE-REDUCTASE [J].
VILLAFRANCA, JE ;
HOWELL, EE ;
VOET, DH ;
STROBEL, MS ;
OGDEN, RC ;
ABELSON, JN ;
KRAUT, J .
SCIENCE, 1983, 222 (4625) :782-788