SEVERE MONOCHLOROBENZENE-INDUCED LIVER-CELL NECROSIS

被引：3

作者：

BABANY, G

BERNUAU, J

CAILLEUX, A

CADRANEL, JF

DEGOTT, C

ERLINGER, S

BENHAMOU, JP

机构：

[1] HOP BEAUJON, SERV ANAT & CYTOL PATHOL, F-92118 CLICHY, FRANCE

[2] HOP BRETONNEAU, SERV PHARMACOL & TOXICOL, ANGERS, FRANCE

[3] HOP BEAUJON, INSERM, U24, UNITE RECH PHYSIOPATHOL HEPAT, F-92118 CLICHY, FRANCE

来源：

GASTROENTEROLOGY | 1991年 / 101卷 / 06期

关键词：

D O I：

10.1016/0016-5085(91)90416-I

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Benzene derivatives can induce severe liver cell necrosis in animals. A case of a 40-year-old man whose daily consumption of alcohol was 200 g and who had a severe monochlorobenzene-induced liver necrosis is described. Liver biopsy specimen showed centrilobular and mediolobular necrosis, similar to that in mice after experimental bromobenzene administration. Monochlorobenzene serum concentration, assayed from day 3 to day 15 after poisoning, decreased monoexponentially with a half-life of 40.3 hours. Prostaglandin E1 was administered from day 3 to day 8. The patient ultimately recovered. The mechanism of monochlorobenzene-induced liver injury and the possible aggravating role of chronic alcohol consumption are discussed. © 1991.

引用

页码：1734 / 1736

页数：3

共 15 条

[1] MULTIVARIATE-ANALYSIS OF PROGNOSTIC FACTORS IN FULMINANT HEPATITIS-B [J].