THE INTRAVENOUS SELF-ADMINISTRATION OF ANTIHISTAMINES BY RHESUS-MONKEYS

被引:28
作者
BEARDSLEY, PM [1 ]
BALSTER, RL [1 ]
机构
[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOL,BOX 613,MCV STN,RICHMOND,VA 23298
关键词
ANTIHISTAMINE; SELF-ADMINISTRATION; RHESUS MONKEY; COCAINE;
D O I
10.1016/0376-8716(92)90016-6
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Rhesus monkeys were trained to lever press for infusions of cocaine during daily, 1-h experimental sessions. Following stabilization of the cocaine-maintained baselines, various antihistamines were substituted for cocaine to determine whether they would be self-administered. The results indicated that all monkeys tested self-administered tripelennamine and chlorpheniramine. One monkey out of the four self-administered pyrilamine, but only at a single (300-mu-g/kg) high dose. Phenyltoloxamine, cimetidine and hydroxyzine were not self-administered. These results further illuminate differences amongst H-1 antagonists in their potential for self-administration and, when examined in context with other reports, suggest that stimulant-like properties may help mediate their reinforcing effects when present.
引用
收藏
页码:117 / 126
页数:10
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