MONO(9-ETHYLGUANINE) AND BIS(9-ETHYLGUANINE) COMPLEXES OF TRANS-(CH3NH2)2PT(II) - X-RAY STRUCTURE OF THE 2/1 COMPLEX AND REDISTRIBUTION OF THE 1/1 COMPOUND

被引：19

作者：

PESCH, FJ ^{[1
]}

WIENKEN, M ^{[1
]}

PREUT, H ^{[1
]}

TENTEN, A ^{[1
]}

LIPPERT, B ^{[1
]}

机构：

[1] UNIV DORTMUND, FACHBEREICH CHEM, W-4600 DORTMUND, GERMANY

来源：

INORGANICA CHIMICA ACTA | 1992年 / 197卷 / 02期

关键词：

D O I：

10.1016/S0020-1693(00)84971-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

trans-[(CH2NH2)2Pt(9-EtGH)Cl]Cl (1) and trans-[(CH3NH2)2Pt(9-EtGH)2]Cl2 (2) with 9-EtGH = 9-ethylguanine have been prepared and studied. Pt binding in both compounds is through N7, as evident from Pt-195-H-1(8) coupling (1) and X-ray crystallography (2), respectively. The X-ray structure of 2 shows the cation to be centrosymmetric, with the two methylamine ligands disordered over two positions. In Me2SO-d6, the cation of 2 forms Watson-Crick hydrogen bonds with added 1-methylcytosine (1-MeC), as shown by concentration-dependent H-1 NMR spectroscopy. The solution behaviour (water) of 1 is remarkable in that it undergoes a partial redistribution according to 2(1) --> (2)+trans-(CH3NH2)2PtCl2 in addition to N7,N1-bridge formation. If realized with DNA, this reaction could facilitate a migration of a monofunctionally bound trans-diamineplatinum(II) entity along DNA or its removal from DNA.

引用

页码：243 / 249

页数：7

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