SYNTHESIS AND BIODISTRIBUTION OF A NEW (99M)TECHNETIUM FATTY-ACID

被引：25

作者：

JONES, GS ^{[1
]}

ELMALEH, DR ^{[1
]}

STRAUSS, HW ^{[1
]}

FISCHMAN, AJ ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP,DEPT RADIOL,PHYS RES LAB,RESH 517,BOSTON,MA 02114

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1994年 / 21卷 / 01期

关键词：

D O I：

10.1016/0969-8051(94)90138-4

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The synthesis and biodistribution is described for a new Tc-99m-labeled fatty acid. The requisite diaminodithiol (N2S2) ligand, 9,10-bis[N-(2'-methyl-2'-mercapto)propyl] aminooctadecanoic acid, was prepared in nine steps from ethyl oleate and characterized by fast atom bombardment mass spectrometry and elemental analysis of its nickell(II) complex. The radiolabeling procedure provided a liposoluble Tc-99m-labeled complex (Tc-99m-11) which was administered intravenously to rats concomitantly with 15-(p-[I-125]-iodophenyl) pentadecanoic acid (IPPA). The myocardial profile of Tc-99m-11 was inferior to that of IPPA.

引用

页码：117 / 123

页数：7

共 17 条

[1] 1-ALKYL ( OR ARYL-)AMINO-2-METHYLPROPANE-2-THIOLS - SOME BIDENTATE AND TETRADENTATE NITROGEN-SULFUR LIGANDS FROM SCHIFFS BASE DISULFIDES [J].

CORBIN, JL ;

WORK, DE .

JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (03) :489-491

[2]

CUMMING S A, 1988, Journal of Nuclear Medicine, V29, P934

[3]

DAVISON A, 1985, J NUCL MED, V26, P4

[4] NEW COMPOUNDS - FATTY-ACID AND LONG-CHAIN HYDROCARBON DERIVATIVES CONTAINING A STRONG CHELATING AGENT [J].

ECKELMAN, WC ;

KARESH, SM ;

REBA, RC .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1975, 64 (04) :704-706

[5] A COLORIMETRIC METHOD FOR DETERMINING LOW CONCENTRATIONS OF MERCAPTANS [J].

ELLMAN, GL .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1958, 74 (02) :443-450

[6]

GOODMAN MM, 1984, J MED CHEM, V27, P380

[7] A CONVENIENT ONE-POT SYNTHESIS OF 2-METHYL-2-BENZYLTHIOPROPANAL [J].

JONES, GS ;

ELMALEH, DR .

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1990, 22 (01) :112-113

[8]

KELSO T, 1988, Journal of Nuclear Medicine, V29, P935

[9] NEW BRAIN PERFUSION IMAGING AGENTS BASED ON TC-99M BIS(AMINOETHANETHIOL) COMPLEXES - STEREOISOMERS AND BIODISTRIBUTION [J].

KUNG, HF ;

GUO, YZ ;

YU, CC ;

BILLINGS, J ;

SUBRAMANYAM, V ;

CALABRESE, JC .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (02) :433-437

[10]

LIEFHOLD J, 1986, 6TH INT S RAD CHEM

← 1 2 →