ABSORPTION OF LIPOSOME-ENCAPSULATED TETRACAINE VERSUS NONLIPOSOME-ENCAPSULATED TETRACAINE FROM OPEN WOUNDS IN RABBITS

被引：7

作者：

FISHER, R ^{[1
]}

MURPHY, M ^{[1
]}

HUNG, O ^{[1
]}

MEZEI, M ^{[1
]}

STEWART, R ^{[1
]}

机构：

[1] DALHOUSIE UNIV,DEPT ANAESTHESIA,HALIFAX B3H 4H2,NS,CANADA

来源：

AMERICAN JOURNAL OF EMERGENCY MEDICINE | 1994年 / 12卷 / 05期

关键词：

LIPOSOME; OPEN WOUNDS; RABBITS; SYSTEMIC ABSORPTION; TETRACAINE;

D O I：

10.1016/0735-6757(94)90268-2

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The plasma tetracaine concentration versus time profiles for liposome-encapsulated tetracaine (LET) versus nonliposome-encapsulated tetracaine (NLET) were determined after topical application to open wounds in six rabbits (three in LET and three in NLET). H3-tetracaine preparations of LET or NLET were applied randomly to uniform dermal lacerations in anesthetized rabbits. Plasma tetracaine concentrations (ng/mL) of arterial blood samples obtained were measured at predetermined intervals (0.25, 0.5, 1.0, 2.0, and 24 hours) by isotope tracer assay. Results (mean ± standard deviation) showed the peak plasma tetracaine concentration (Cmax) and the time to Cmax were 40.8 ± 5.1 ng/ml and 40.1 ± 7.3 minutes for LET, and 117.8 ± 9.7 ng/mL and 49.1 ± 50.2 minutes for NLET. Plasma tetracaine concentrations at all samples times were significantly lower for LET versus NLET. Liposome encapsulation of topically applied tetracaine significantly decreases both the peak and overall plasma tetracaine concentrations compared with the nonencapsulated form. The data suggest that liposome encapsulation of topically applied local anesthetics such as a solution of tetracaine, adrenaline, and cocaine, might reduce the potential systemic toxicity caused by rapid absorption of these compounds. © 1994.

引用

页码：521 / 523

页数：3

共 26 条

[1]

Schaffer, Clinical comparison of TAC anesthetic solutions with and without cocaine, Annals of Emergency Medicine, 14, pp. 1077-1080, (1985)

[2]

Dronen, Complications of TAC, Annals of Emergency Medicine, 12, (1983)

[3]

Dailey, Fatality secondary to misuse of TAC solution, Annals of Emergency Medicine, 17, pp. 159-160, (1988)

[4]

Fitzmaurice, Wasserman, Knapp, Et al., TAC use and absorption of cocaine in a pediatric emergency department, Annals of Emergency Medicine, 19, pp. 515-518, (1990)

[5]

Gesztes, Mezei, Topical Anesthesia of the Skin by Liposome-Encapsulated Tetracaine, Anesthesia & Analgesia, 67, pp. 1079-1081, (1988)

[6]

Foldvari, Gesztes, Mezei, Dermal drug delivery by liposome encapsulation: Clinical and electron microscopic studies, Journal of Microencapsulation, 7, pp. 479-489, (1990)

[7]

Hansen, Reynolds, Foldvari, Topical liposomal tetracaine for i.v. cannulation., Can J Anaesth, 37, (1990)

[8]

Smith, Prieskorn, Knutsen, Et al., A method for frequent blood sampling in rabbits., Lab Anim Sci, 38, pp. 623-625, (1988)

[9]

Osborne, Richardson, Payne, Et al., Technetium-99m labeled liposome axillary lymphoscintigraphy in breast cancer, Clin Oncol (R Coll Radiol), 6, pp. 289-290, (1980)

[10]

Osborne, Payne, Richardson, Et al., The preoperative detection of axillary lymph node metastases in breast cancer by isotope imaging, British Journal of Surgery, 70, pp. 141-144, (1983)

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