THERMOTOLERANCE IN HUMAN GLIOMA-CELLS

被引:12
作者
RAAPHORST, GP
MAO, J
NG, CE
机构
[1] Ottawa Regional Cancer Centre, Ottawa, ON, K1Y 4K7
关键词
HYPERTHERMIA; GLIOMA; THERMOTOLERANCE;
D O I
10.3109/02656739509022487
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Human glioma cells held in plateau phase were tested for the development of chronic and acute thermotolerance. Long duration, mild hyperthermia at 39-42 degrees C for up to 48 h showed no development of chronic thermotolerance. Heating at 45 degrees C immediately after mild hyperthermia showed that acute thermotolerance did develop for 40-42 degrees C heating. This thermotolerance developed at about the same rate for the three inducing temperatures (40-42 degrees C) but the decay characteristics were temperature dependent. In fact, for 42 degrees C heating thermosensitization to subsequent 45 degrees C heating was achieved after 48 h of heating. These data show that chronic and acute thermotolerance may be different in human glioma cells.
引用
收藏
页码:523 / 529
页数:7
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