A METHYL VIOLOGEN-SENSITIVE MUTANT OF THE NEMATODE CAENORHABDITIS-ELEGANS

被引：176

作者：

ISHII, N

TAKAHASHI, K

TOMITA, S

KEINO, T

HONDA, S

YOSHINO, K

SUZUKI, K

机构：

[1] SHOWA UNIV, FUJIGAOKA HOSP, RADIOISOTOPE LAB, MIDORI KU, YOKOHAMA 227, JAPAN

[2] INST CONTROL AGING, FUKUROI, SHIZUOKA 43701, JAPAN

[3] CELCI COSMET CO, TOKYO INST, EDOGAWA KU, TOKYO 132, JAPAN

[4] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL, ISOTOPE LAB, ITABASHI KU, TOKYO 173, JAPAN

来源：

MUTATION RESEARCH | 1990年 / 237卷 / 3-4期

关键词：

Caenorhabditis elegans; Life span; Oxygen toxicity; Paraqua-sensitive mutant;

D O I：

10.1016/0921-8734(90)90022-J

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A methyl violagen (paraquat)-sensitive mutant, mev-1 (LG III), in Caenorhabditis elegans was about 4 times more sensitive to methyl viologen than the wild type. This mutant was also hypersensitive to oxygen. The brood size was about 1 4 that of the wild type. The average life span was determined to be 9.3 days as compared to 14.3 days for the wild type. The activity of superoxide dismutase (SOD), a scavenging enzyme for superoxide anion, was about half the wild-type level. We suggest that oxygen radicals may be involved in the normal aging mechanism in C. elegans. © 1990.

引用

页码：165 / 171

页数：7

共 30 条

[1] SUPEROXIDE MEDIATES THE TOXICITY OF PARAQUAT FOR CHINESE-HAMSTER OVARY CELLS [J].