REPAIR OF CHRONIC TYMPANIC MEMBRANE PERFORATIONS USING APPLICATIONS OF HYALURONAN OR RICE PAPER PROSTHESES

被引：30

作者：

LAURENT, C

SODERBERG, O

ANNIKO, M

HARTWIG, S

机构：

[1] Department of Otorhinolaryngology, Central Hospital, Falun

[2] Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital, University of Umeå

来源：

ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 1991年 / 53卷 / 01期

关键词：

HYALURONAN; HYALURONIC ACID; RICE PAPER; TYMPANIC MEMBRANE PERFORATION; MYRINGOPLASTY; HIGH-FREQUENCY AUDIOMETRY; WOUND HEALING;

D O I：

10.1159/000276182

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

A controlled randomized study was performed in 60 patients with 64 chronic, dry tympanic membrane (TM) perforations. The perforations were randomly allocated to either resection of the perforation rim and instillation of 1% hyaluronan (Healon (R); HYA) in the perforation gap once daily for 7 days (33 ears) or resection of the perforation margin and application of a sterile rice paper prosthesis (31 ears). The treatment effect was documented by TM photography and morphometric measurements of the perforation area. The hearing was assessed with pure-tone and high-frequency audiometry. After 2 months, 5 of the HYA-treated perforations (15%) and 4 of the rice-paper-treated TMs (13%) were healed. After 1 year, 18 perforations (9 in each treatment group) were healed. In neither group were there any persistent adverse effects on hearing. It is noteworthy that 28% (18/64) of the chronic, long-standing TM perforations could be repaired by these technically simple and time-saving methods. Both procedures should be considered as easy first-choice alternatives to myringoplasty in selected cases.

引用

页码：37 / 40

页数：4

共 19 条

[1]

Per-Lee J.H., Long-term middle ear ventilation, Laryngoscope, 91, pp. 1063-1073, (1981)

[2]

Karma P., Sipila M., Kokko E., Long-term results of tympanostomy treatment in chronic secretory otitis media, Acta Otolaryngol Suppl (Stockh), 386, pp. 163-165, (1982)

[3]

Fiebach A., Matschke R.G., Verweildauer und Komplikationen nach Paukenrohrcheneinlage im Kindesalter, HNO, 35, pp. 61-66, (1987)

[4]

Lindeman P., Edstrom S., Granstrom G., Et al., Acute traumatic tympanic membrane perforations. Cover or observe?, Arch Otolaryngol, 113, pp. 1285-1287, (1987)

[5]

Laurent C., Hyaluronan in the Middle Ear. An Experimental Background to the Evaluation of Its Possible Benefits in Otosurgery, 211, (1988)

[6]

Laurent C., Hellstrom S., Fellenius E., Hyaluronan improves the healing of experimental tympanic membrane perforations. A comparison of preparations with different rheologic properties, Arch Otolaryngol, 114, pp. 1435-1441, (1988)

[7]

Stenfors L.-E., Treatment of tympanic mebrane perforations with hyaluronan in an open pilot study of unselected patients, Acta Otolaryngol Suppl (Stockh), 442, pp. 81-87, (1987)

[8]

Stenfors L.-E., Repair of tympanic membrane perforations using hyaluronic acid: An alternative to myringoplasty, J Laryngol Otol, 103, pp. 39-40, (1989)

[9]

Strohm M., Tympanic membrane lesions, Trauma of the Middle Ear. Clinical Findings, Postmortem Observations and Results of Experimental Studies, 35, pp. 20-21, (1986)

[10]

Senturia B.H., Paparella M.W., Lowery H.W., Et al., Report of research conference on recent advances in otitis media with effusion. Panel I-A, Definition and Classification Ann Otol Rhinol Laryngol, 89, pp. 4-8, (1980)

← 1 2 →