A PRELIMINARY INVESTIGATION INTO THE PHENOMENON OF ORAL TOLERANCE IN RAINBOW-TROUT (ONCORHYNCHUS-MYKISS, WALBAUM, 1792)

被引：32

作者：

DAVIDSON, GA ^{[1
]}

ELLIS, AE ^{[1
]}

SECOMBES, CJ ^{[1
]}

机构：

[1] UNIV ABERDEEN,DEPT ZOOL,ABERDEEN AB9 2TN,SCOTLAND

来源：

FISH & SHELLFISH IMMUNOLOGY | 1994年 / 4卷 / 02期

关键词：

ORAL ANAL ANTIGEN DELIVERY; IMMUNE SUPPRESSION; RAINBOW TROUT; (AEROMONAS-SALMONICIDA);

D O I：

10.1006/fsim.1994.1012

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Interactions between the systemic and mucosal immune compartments of rainbow trout, Oncorhynchus mykiss, were investigated. Pre-exposure to antigen daily via the oral route for 5 to 10 days or by a single intraperitoneal (i.p.) injection was found to have no effect on the systemic response to human gamma-globulin (HGG) administered i.p. 35 days later. However, when HGG was administered simultaneously via the oral and i.p. routes or anal and i.p. routes (oral or anal administration of HGG being continued twice weekly for 8 weeks) the serum antibody response was significantly delayed. Moreover, a partial (oral route) to complete (anal route) suppression of circulating anti-HGG antibody titre was observed which was dependent on the dose of antigen delivered via the enteric route. When the same oral route experiment was performed using Aeromonas salmonicida as an antigen no suppression of the systemic antibody response was observed, indeed, an enhancement of the response was apparent.

引用

页码：141 / 151

页数：11

共 27 条

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