POSITIVE SELECTION OF T-CELLS

被引：74

作者：

FOWLKES, BJ

SCHWEIGHOFFER, E

机构：

[1] Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Building 4

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 02期

关键词：

D O I：

10.1016/0952-7915(95)80003-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the past year, significant technical developments have provided the opportunity to investigate the more mechanistic features of positive selection. Major progress has been made in determining the structure and function of the early pre-T cell receptor, in defining cell types that mediate positive selection, and in analyzing the contribution of MHC and co-receptors to CD4/CD8 lineage commitment. The most revealing studies have been those addressing the role of peptides in thymic selection.

引用

页码：188 / 195

页数：8

共 54 条

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[2] THYMIC EPITHELIAL-CELLS PROVIDE UNIQUE SIGNALS FOR POSITIVE SELECTION OF CD4+CD8+ THYMOCYTES IN-VITRO
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[5] EVIDENCE FOR A DIFFERENTIAL AVIDITY MODEL OF T-CELL SELECTION IN THE THYMUS
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[6] A SUBSET OF CD4(+) THYMOCYTES SELECTED BY MHC CLASS-I MOLECULES
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[7] REGULATION OF RAG-1 AND CD69 EXPRESSION IN THE THYMUS DURING POSITIVE AND NEGATIVE SELECTION
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[8] ZAP-70 DEFICIENCY IN AN AUTOSOMAL RECESSIVE FORM OF SEVERE COMBINED IMMUNODEFICIENCY
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[9] ROLE OF CORECEPTORS IN POSITIVE SELECTION AND LINEAGE COMMITMENT
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[J]. EMBO JOURNAL, 1994, 13 (19) : 4482 - 4489
[10] ANOTHER VIEW OF THE SELECTIVE MODEL OF THYMOCYTE SELECTION
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