TISSUE-PLASMINOGEN ACTIVATOR, PLASMINOGEN-ACTIVATOR INHIBITOR-1 AND VON-WILLEBRAND-FACTOR IN RHEUMATOID-ARTHRITIS

被引：35

作者：

WALLBERGJONSSON, S

DAHLEN, GH

NILSSON, TK

RANBY, M

RANTAPAADAHLQVIST, S

机构：

[1] Department of Rheumatology, University Hospital, Umeå

[2] Department of Clinical Chemistry, University Hospital, Umeå

[3] Institution of Medical Biochemistry, University of Umeå

来源：

CLINICAL RHEUMATOLOGY | 1993年 / 12卷 / 03期

关键词：

TISSUE PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR INHIBITOR-1 VON-WILLEBRAND FACTOR; FIBRINOLYSIS; RHEUMATOID ARTHRITIS;

D O I：

10.1007/BF02231572

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF), all of endothelial origin and active in the haemostasis, were analysed in 74 patients with rheumatoid arthritis. The concentrations were related to extra-articular disease and to the incidence of thromboembolic events (TE) registered in a 2-year follow-up period. Patients with extra-articular disease had a significant increase in PAI-1 activity and reduced tPA release in the venous occlusion test. von Willebrand factor, PAI-1 and also haptoglobin and triglycerides were significantly increased in the group of patients who later suffered from TE. In a multiple regression model, in which cholesterol, triglycerides and lipoprotein (a) showed significant association with TE, vWF had the strongest additive explanatory value. No distinct acute phase pattern of PAI-1 was found in any patient subgroup.

引用

页码：318 / 324

页数：7

共 35 条

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