SYNTHESIS OF NOVEL BORON-CONTAINING POLYAMINES - AGENTS FOR DNA TARGETING IN NEUTRON-CAPTURE THERAPY

被引：24

作者：

HARIHARAN, JR ^{[1
]}

WYZLIC, IM ^{[1
]}

SOLOWAY, AH ^{[1
]}

机构：

[1] OHIO STATE UNIV,COLL PHARM,COLUMBUS,OH 43210

来源：

POLYHEDRON | 1995年 / 14卷 / 06期

关键词：

D O I：

10.1016/0277-5387(94)00497-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new class of carriers for Neutron Capture Therapy, boronated polyamines, are presented that may possess a high affinity for DNA and rapid/specific uptake in brain tumors by comparison with adjacent normal brain. Two first boron-containing polyamines such as 1,8-diamino-4-(4-o-carboranylbutyl)-4-azaoctane and 1,8-diamino-4-(3-o-carboranylpropyl)-4-azaoctane were synthesized via silylation-alkylation reaction of bis-Boc-protected spermidine with either carboranyl iodides or tosylates.

引用

页码：823 / 825

页数：3

共 22 条

[1] SYNTHESIS OF A CARBORANYL NUCLEOSIDE FOR POTENTIAL USE IN NEUTRON-CAPTURE THERAPY OF CANCER [J].