STUDIES ON MECHANISM OF ACTION OF GLYCYRRHIZIN AGAINST HEPATITIS-A VIRUS-REPLICATION IN-VITRO

被引：70

作者：

CRANCE, JM

LEVEQUE, F

BIZIAGOS, E

VANCUYCKGANDRE, H

JOUAN, A

DELOINCE, R

机构：

[1] Unité de Biologie Moléculaire, Centre de Recherches, Service de Santé des Armées, 38702 La Tronche Cedex

来源：

ANTIVIRAL RESEARCH | 1994年 / 23卷 / 01期

关键词：

HEPATITIS A VIRUS; GLYCYRRHIZIN; VIRUS PENETRATION;

D O I：

10.1016/0166-3542(94)90033-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Glycyrrhizin (GL) achieved a concentration-dependent inhibition of the replication of hepatitis A virus (HAV) in PLC/PRF/5 cells. GL has been shown to inhibit an early stage of the HAV replication. GL was not virucidal and had no measurable effect on the adsorption of [H-3]uridine-labelled virions to cells. GL inhibited HAV penetration of the plasma membrane as measured by the amount of infective virus no longer neutralizable by specific antibody over time.

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页码：63 / 76

页数：14

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