ADJUVANT QUIL-A IMPROVES PROTECTION IN MICE AND ENHANCES OPSONIC CAPACITY OF ANTISERA INDUCED BY PNEUMOCOCCAL POLYSACCHARIDE CONJUGATE VACCINES

被引：21

作者：

ALONSODEVELASCO, E

DEKKER, HAT

ANTAL, P

JALINK, KP

VANSTRIJP, JAG

VERHEUL, AFM

VERHOEF, J

SNIPPE, H

机构：

[1] Eijkman-Winkler Institute of Medical Microbiology, Utrecht University, 3584 CX Utrecht, Heidelberglaan 100

来源：

VACCINE | 1994年 / 12卷 / 15期

关键词：

QUIL A; OPSONIZATION; STREPTOCOCCUS PNEUMONIAE;

D O I：

10.1016/0264-410X(94)90151-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The adjuvant effect of Quil A on the primary antibody response of mice to pneumococcal capsular polysaccharide conjugates was examined. Quil A increased the anti-capsular polysaccharide antibody titres, the protection against Streptococcus pneumoniae, and the opsonic capacity of the antibodies as measured in a newly developed in vitro phagocytosis assay, using the mouse macrophage cell line J774.

引用

页码：1419 / 1422

页数：4

共 16 条

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