GASTRIC ACID-INDEPENDENT ENHANCEMENT OF EXOCRINE PANCREATIC-SECRETION BY DIETARY-PROTEIN IN CHRONIC BILE-PANCREATIC JUICE DIVERTED RATS

被引：6

作者：

HARA, H

NARAKINO, H

KIRIYAMA, S

机构：

[1] Department of Bioscience and Chemistry, Hokkaido University, Sapporo

来源：

PANCREAS | 1995年 / 11卷 / 02期

关键词：

EXOCRINE PANCREATIC SECRETION; DIETARY PROTEIN; BILE PANCREATIC JUICE DIVERSION; GASTRIC ACID SECRETION; OMEPRAZOLE; RATS;

D O I：

10.1097/00006676-199508000-00010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Diversion of bile-pancreatic juice (BPJ) causes exocrine pancreatic hypersecretion in a fasting state, and we demonstrated that a feeding of dietary protein stimulates further secretion of pancreatic enzymes in chronic BPJ-diverted rats. We determined that gastric acid secretion is associated with the stimulatory effect of dietary protein feeding on pancreatic secretion in the diverted rats. BPJ was diverted with a cannula of the common bile-pancreatic duct and returned to the upper ileum for 7 days. The BPJ-diverted rats were administered omeprazole (12 mg/kg body weight) orally and were fed a 25% casein, fat-free diet spontaneously under unrestrained conditions. The volume of BPJ was not changed after administration of omeprazole and feeding the diet. Total protein, amylase, and chymotrypsin secretions were not changed 1 h after omeprazole administration but increased gradually after feeding the diet. The secretion of these enzymes reached peak values 120-150 min after feeding, and these values were two- to threefold higher than those before feeding. We conclude that gastric acid secretion is not responsible for the stimulation of pancreatic secretion that occurs after feeding a dietary protein to chronic BPJ-diverted rats.

引用

页码：173 / 178

页数：6

共 21 条

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