MALEOPIMARIC ACID - A POTENT SENSITIZER IN MODIFIED ROSIN

被引：27

作者：

KARLBERG, AT

GAFVERT, E

HAGELTHORN, G

NILSSON, JLG

机构：

[1] UNIV UPPSALA,DEPT ORGAN PHARMACEUT CHEM,S-75105 UPPSALA,SWEDEN

[2] KAROLINSKA HOSP,S-10401 STOCKHOLM 60,SWEDEN

来源：

CONTACT DERMATITIS | 1990年 / 22卷 / 04期

关键词：

allergic contact dermatitis; CCET; colophony; FCAT; guinea pigs; maleic‐modified rosin; maleopimaric acid; rosin; structural elucidation; synthesis;

D O I：

10.1111/j.1600-0536.1990.tb01566.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The allergenicity of the maleic‐modified rosins and their esters has been studied. The unesterified resins arc mainly used in paper size and the esters in printing inks, varnishes and adhesives. The levopimaric‐maleic anhydride Diels‐Alder adduct (maleopimaric acid) is the main component obtained in the maleic‐modified rosins. This compound was synthesized and its structure was determined. Its sensitising potential was investigated in guinea pigs according to different methods. It was shown that maleopimaric acid is a very potent sensitizer, comparable with the strongest allergen isolated from unmodified gum rosin. The allergen may also be present after esterification lion unless the process is carried out to completion. The animals sensitized to maleopimaric acid did not react to unmodified rosin, which shows that maleopimaric acid is structurally different from the allergens in rosin. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：193 / 201

页数：9

共 29 条

[1]

ANDERSEN KE, 1985, CURR PROBL DERM, V14

[2] STEREOCHEMISTRY OF MALEOPIMARIC ACID AND LONG RANGE SHIELDING EFFECT OF OLEFINIC BOND [J].