S,N-HETEROCYCLES .4. STRUCTURE-ACTIVITY RELATIONSHIP OF OPTICALLY-ACTIVE 2-(3-PYRIDYL)THIAZOLIDIN-4-ONES AS A PAF ANTAGONIST

被引：70

作者：

TANABE, Y

SUZUKAMO, G

KOMURO, Y

IMANISHI, N

MOROOKA, S

ENOMOTO, M

KOJIMA, A

SANEMITSU, Y

MIZUTANI, M

机构：

[1] SUMITOMO PHARMACEUT CO LTD,RES LABS,KONOHANA KU,OSAKA 554,JAPAN

[2] SUMITOMO CHEM CO LTD,TAKARAZUKA RES CTR,AGR SCI RES LAB,TAKARAZUKA,HYOGO 665,JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 03期

关键词：

D O I：

10.1016/S0040-4039(00)92633-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two sets of optically active 5-substituted-2-(3-pyridyl)thiazolidin-4-ones, highly potent and selective antagonists of platelet activating factor (PAF), displayed apparently different anti-PAF activities between their enantiomers, wherein these activities depend markedly on the absolute configuration of the 2-position in the thiazolidin-4-ones.

引用

页码：379 / 382

页数：4

共 12 条

[1]

CHANG M N, 1986, Drugs of the Future, V11, P869

[2] DUAL BINDING MODES TO THE RECEPTOR FOR PLATELET ACTIVATING FACTOR (PAF) OF ANTI-PAF TRANS-2,5-DIARYLFURANS [J].