HEPARAN-SULFATE AS A VENOSTATIC ENDOTHELIAL STABILIZING FACTOR

被引：5

作者：

HLADOVEC, J ^{[1
]}

KORNALIK, F ^{[1
]}

机构：

[1] CHARLES UNIV, FAC MED, INST PATHOPHYSIOL, CS-11636 PRAGUE 1, CZECHOSLOVAKIA

来源：

THROMBOSIS RESEARCH | 1992年 / 68卷 / 06期

关键词：

VENOSTASIS; HEPARAN SULFATE; ENDOTHELIUM; ANTIPROLIFERATIVE EFFECT;

D O I：

10.1016/0049-3848(92)90058-I

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A humoral transfer of a factor inducing a decrease of circulating endothelial cells (CEC) released during venostasis was demonstrated in rats. The possibility to block its activity by an in-vitro addition of protamine suggests its identity with an endogenous heparan sulfate possessing an inhibitory effect on endothelial turnover. This was supported by an analogous effect of intravenously administered heparan sulfate-related agent.

引用

页码：459 / 465

页数：7

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