DEVELOPMENTAL-CHANGES IN THE VOLTAGE-DEPENDENCE OF NEOCORTICAL NMDA RESPONSES

被引：31

作者：

BURGARD, EC

HABLITZ, JJ

机构：

[1] UNIV ALABAMA,NEUROBIOL RES CTR,BIRMINGHAM,AL 35294

[2] UNIV ALABAMA,DEPT PHYSIOL & BIOPHYS,BIRMINGHAM,AL 35294

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1994年 / 80卷 / 1-2期

关键词：

NMDA; NEOCORTEX; DEVELOPMENT; GLUTAMATE; MAGNESIUM; PATCH CLAMP;

D O I：

10.1016/0165-3806(94)90113-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A change in the response of neocortical neurons to N-methyl-D-aspartate (NMDA) was observed during the first 2 weeks of postnatal development. When NMDA was bath applied, the membrane current-voltage relationship recorded in neurons from postnatal day (PN) 3-5 rats displayed a region of decreased inward current at hyperpolarized membrane potentials. By PN 9-14, the net inward current at hyperpolarized potentials was significantly less than that recorded in PN 3-5 neurons. These results indicate that a developmental increase in the voltage-dependence of NMDA responses exists, which may be due to changes in magnesium sensitivity of the NMDA receptor.

引用

页码：275 / 278

页数：4

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