AN EFFICIENT ROUTE TO S-N-(9-FLUORENYLMETHOXYCARBONYL)-4'-(1-AZI-2,2,2-TRIFLUOROETHYL)PHENYLALANINE

被引：35

作者：

FISHWICK, CWG ^{[1
]}

SANDERSON, JM ^{[1
]}

FINDLAY, JBC ^{[1
]}

机构：

[1] UNIV LEEDS,DEPT BIOCHEM & MOLEC BIOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(00)60743-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An extremely efficient synthesis of optically pure photoactivatable phenylalanine derivative 1 is described. The key step involves a highly diastereoselective alkylation of a chiral glycine equivalent.

引用

页码：4611 / 4614

页数：4

共 6 条

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[3] AN IMPROVED SYNTHESIS OF 4-[3-(TRIFLUOROMETHYL)-3H-DIAZIRIN-3-YL]BENZOIC ACID FOR PHOTOAFFINITY-LABELING
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[J]. HETEROCYCLES, 1993, 35 (02) : 997 - 1004
[4] 4'-(1-AZI-2,2,2-TRIFLUOROETHYL)PHENYLALANINE, A PHOTOLABILE CARBENE-GENERATING ANALOG OF PHENYLALANINE
NASSAL, M
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (24) : 7540 - 7545
[5] PHOTOLYSIS OF 3-ARYL-3-(TRIFLUOROMETHYL)DIAZIRINES - A CAVEAT REGARDING THEIR USE IN PHOTOAFFINITY PROBES
PLATZ, M
ADMASU, AS
KWIATKOWSKI, S
CROCKER, PJ
IMAI, N
WATT, DS
[J]. BIOCONJUGATE CHEMISTRY, 1991, 2 (05) : 337 - 341
[6] SHIH LY, 1983, ANAL BIOCHEM, V144, P132

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