PROTECTIVE ACTION OF IDEBENONE AGAINST EXCITOTOXIC DEGENERATION IN CULTURED CORTICAL-NEURONS

被引：20

作者：

BRUNO, V

BATTAGLIA, G

COPANI, A

SORTINO, MA

CANONICO, PL

NICOLETTI, F

机构：

[1] UNIV CATANIA,SCH MED,INST PHARMACOL,I-95125 CATANIA,ITALY

[2] UNIV PAVIA,SCH DENT,CHAIR PHARMACOL,I-27100 PAVIA,ITALY

[3] UNIV PERUGIA,DEPT EXPTL MED & BIOCHEM SCI,PHARMACOL SECT,I-06100 PERUGIA,ITALY

来源：

NEUROSCIENCE LETTERS | 1994年 / 178卷 / 02期

关键词：

NMDA; KAINATE; EXCITOTOXICITY; IDEBENONE; FREE RADICAL; CORTICAL CULTURE;

D O I：

10.1016/0304-3940(94)90757-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The novel free radical scavenger and electron-trapping agent, idebenone, protects cultured cortical neurons against necrotic degeneration induced by either a brief exposure to N-methyl-D-aspartate (NMDA) or a prolonged exposure to kainate. As opposed to the NMDA receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5, 10-imine hydrogen maleate (MK801), idebenone rescued cortical neurons even when applied 30 min after the NMDA pulse, suggesting that the drug interferes with the chain of toxic reactions triggered by an excessive stimulation of excitatory amino acid receptors.

引用

页码：193 / 196

页数：4

共 17 条

[1] DO NMDA ANTAGONISTS PREVENT NEURONAL INJURY - YES [J].