CEREBRODIENE - A BRAIN LIPID ISOLATED FROM SLEEP-DEPRIVED CATS

被引：105

作者：

LERNER, RA ^{[1
]}

SIUZDAK, G ^{[1
]}

PROSPEROGARCIA, O ^{[1
]}

HENRIKSEN, SJ ^{[1
]}

BOGER, DL ^{[1
]}

CRAVATT, BF ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 20期

关键词：

D O I：

10.1073/pnas.91.20.9505

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report the isolation of a heretofore unrecognized brain lipid that is present in cerebrospinal fluid of sleep-deprived cats. The molecule appears to be a long-chain base structurally related to sphingosine and sphinganine in which a second unsaturated bond has been introduced. An increase in the degree of unsaturation of a key membrane component is expected to have important physiological consequences.

引用

页码：9505 / 9508

页数：4

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