GPI-ANCHOR BIOSYNTHESIS

被引：123

作者：

TAKEDA, J

KINOSHITA, T

机构：

[1] Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, 565

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 09期

关键词：

D O I：

10.1016/S0968-0004(00)89078-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many eukaryotic proteins bind to membranes using a glycosylphosphatidylinositol (GPI) anchor. GPI anchors are essential in yeasts and probably also in protozoa. Although mammalian Cells can survive without GPI anchors, their deficiency in haemopoietic cells causes a haemolytic disease, paroxysmal nocturnal haemoglobinuria (PNH). Here, we discuss recent progress in our understanding of GPI-anchor biosynthesis that could lead to a better understanding of PNH and chemotherapeutic agents to treat protozoal and fungal infections.

引用

页码：367 / 371

页数：5

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