GROWTH INHIBITORY ACTIVITIES IN AVASCULAR TISSUES ARE RECOGNIZED BY ANTI-TRANSFORMING GROWTH-FACTOR-BETA ANTIBODIES

被引：24

作者：

EISENSTEIN, R

GRANTBERTACCHINI, D

机构：

[1] Department of Pathology and Laboratory Medicine, Sinai Samaritan Medical Center, University of Wisconsin Medical School, Milwaukee Clinical Campus, Milwaukee, WI, 53233

来源：

CURRENT EYE RESEARCH | 1991年 / 10卷 / 02期

关键词：

D O I：

10.3109/02713689109001743

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The aqueous and vitreous humors are normally avascular and may be sites of altered inflammatory responses. Inhibitors of endothelial cell and lymphocyte growth as well as of angiogenesis have been isolated from vitreous and an inhibitor of lymphocyte mitogenesis has been found in aqueous. Data are presented here indicating that aqueous humor also inhibits endothelial cell growth. In addition, neutralizing antibodies against TGF-beta block the effects of materials isolated from these tissues on endothelial cell and lymphocyte growth. Similar data were obtained from aorta, another normally avascular site. These observations suggest that the avascularity and altered inflammatory responses in these sites may be regulated in part by TGF-beta.

引用

页码：157 / 162

页数：6

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