OCTREOTIDE INHIBITS INCREASES IN SHORT-CIRCUIT CURRENT INDUCED IN RAT COLON BY VIP, SUBSTANCE-P, SEROTONIN AND AMINOPHYLLINE

被引：19

作者：

FASSLER, JE ^{[1
]}

ODORISIO, TM ^{[1
]}

MEKHJIAN, HS ^{[1
]}

GAGINELLA, TS ^{[1
]}

机构：

[1] OHIO STATE UNIV,DEPT INTERNAL MED,COLUMBUS,OH 43210

来源：

REGULATORY PEPTIDES | 1990年 / 29卷 / 2-3期

关键词：

Octreotide; Short circuit current;

D O I：

10.1016/0167-0115(90)90082-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the effect of octreotide (OCT), a stable somatostatin analog, (OCT) on changes in short-circuit current (Isc) induced by vasoactive intestinal peptide (VIP), aminophylline, serotonin (5-HT) and substance P. OCT significantly decreased basal Isc at a concentration of 10-9 M; the maximum decrease in Isc was observed at 10-6 M. OCT (10-7 M) significantly inhibited the intestinal secretory response to all the secretagogues studied. The maximum Isc response was reduced when tissues were stimulated with VIP (184.9 ± 18.0 vs. 119.7 ± 14.1, P < 0.05), 5-HT (135.1 ± 14.4 vs. 79.5 ± 13.4, P < 0.05) and substance P (156.0 ± 19.2 vs. 30.7 ± 5.4, P < 0.01). In the case of aminophylline, the concentration - response curve was shifted to the right but the maximum response was not reduced. Because VIP and aminophylline increase cAMP while 5-HT and substance P stimulate intestinal secretion principally by a calcium linked mechanism, we conclude that OCT inhibits Isc in rat colon by more than one mechanism. © 1990.

引用

页码：189 / 197

页数：9

共 27 条

[1] DISTRIBUTION, ONTOGENY AND ULTRASTRUCTURE OF SOMATOSTATIN IMMUNOREACTIVE CELLS IN PANCREAS AND GUT [J].