EXPRESSIONS OF RECEPTOR GENE FOR HEPATOCYTE GROWTH-FACTOR IN KIDNEY AFTER UNILATERAL NEPHRECTOMY AND RENAL INJURY

被引：55

作者：

ISHIBASHI, K ^{[1
]}

SASAKI, S ^{[1
]}

SAKAMOTO, H ^{[1
]}

HOSHINO, Y ^{[1
]}

NAKAMURA, T ^{[1
]}

MARUMO, F ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC SCI,DEPT BIOL,FUKUOKA 812,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)90465-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The renal expressions of the receptor gene (c-met) for hepatocyte growth factor (HGF) were examined in unilateral nephrectomy (UNX), renal ischemia or folic acid administration. The levels of c-met mRNA were increased rapidly in all rat models at 6h after the operations. On the other hand, the expression of c-met mRNA in a kidney cell line (MDCK cells) was down-regulated for 8 h after HGF addition, indicating that c-met mRNA induction in rat models may be independent of the stimulated production of HGF. The stimulated expression of c-met in these models suggest that HGF may play an important role in renal hypertrophy after UNX and regeneration after ischemic or nephrotoxic injury. © 1992.

引用

页码：1454 / 1459

页数：6

共 32 条

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