CYCLIC GUANOSINE-MONOPHOSPHATE (CGMP), NITRITE AND NITRATE IN THE CEREBROSPINAL-FLUID IN MENINGITIS, MULTIPLE-SCLEROSIS AND GUILLAIN-BARRE-SYNDROME

被引：26

作者：

IKEDA, M

SATO, I

MATSUNAGA, T

TAKAHASHI, M

YUASA, T

MUROTA, S

机构：

[1] Department of Physiological Chemistry, Graduate School, Tokyo

[2] Department of Neurology, School of Medicine, Tokyo Medical and Dental University, Tokyo

[3] Department of Neurology, Asahi General Hospital, Chiba

来源：

INTERNAL MEDICINE | 1995年 / 34卷 / 08期

关键词：

NITRIC OXIDE; BACTERIAL MENINGITIS; ASEPTIC MENINGITIS;

D O I：

10.2169/internalmedicine.34.734

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent evidence suggests the involvement of nitric oxide (NO) in inflammation and demyelination in the brain. To test this hypothesis, we measured NO markers in the cerebrospinal fluid from patients with bacterial meningitis (BM), aseptic meningitis (AM), multiple sclerosis (MS), and Guillain-Barre syndrome (GBS). Subjects with non-inflammatory neurologic diseases served as the controls, NO markers were cyclic guanosine monophosphate (cGMP) measured with an enzyme immunoassay, and nitrite and nitrate measured with the Griess reaction. Except for BM, cGMP was not increased in AM, MS or GBS compared with the controls. Nitrite and nitrate were unaltered in any of the groups studied. These results do not support the hypothesis that NO is increased in the brain in meningitis, MS or GBS. Otherwise cGMP, nitrite and nitrate in the cerebrospinal fluid do not reflect the increase in NO in the brain.

引用

页码：734 / 737

页数：4

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