OXIDATIVE DEAMINATION OF ALIPHATIC-AMINES BY RAT AORTA SEMICARBAZIDE-SENSITIVE AMINE OXIDASE

被引：71

作者：

YU, PH

机构：

[1] Neuropsychiatric Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 0W0, Cancer and Medical Research Building

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1990年 / 42卷 / 12期

关键词：

D O I：

10.1111/j.2042-7158.1990.tb07048.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rat aorta semicarbazide-sensitive amine oxidase (SSAO) exhibits very high affinity in the deamination of an homologous series of aliphatic amines of 1 to 18 straight chain carbon atoms. The K(m) value decreases substantially as the chain length of these amines increases. The V(max) values are higher for the short chain amines. Diamines are poor substrates for SSAO or are not acted upon by the enzyme. The substrate preference for SSAO differs from that for monoamine oxidase.

引用

页码：882 / 884

页数：3

共 24 条

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