ACID-BASE EQUILIBRIA OF BETA-BLOCKERS IN ACETONITRILE

被引：8

作者：

BARBOSA, J

SANZNEBOT, V

TORRERO, ME

机构：

[1] Department of Analytical Chemistry, University of Barcelona

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1990年 / 8卷 / 8-12期

关键词：

EQUILIBRIUM CONSTANTS; BETA-ADRENOCEPTOR BLOCKING DRUGS; ACETONITRILE; NONAQUEOUS TITRATION;

D O I：

10.1016/0731-7085(90)80101-T

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The acid-base equilibria of a series of beta-adrenoceptor blocking drugs in acetonitrile have been studied, and pK(HB)+ values determined. The theory of such titrations is discussed and simple potentiometric and visual methods in acetonitrile media are proposed for the assay of beta-adrenoceptor blocking drugs.

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页码：675 / 679

页数：5

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