5 ADULTS WITH MILD SICKLE-CELL ANEMIA SHARE A BETA-S-CHROMOSOME WITH THE SAME HAPLOTYPE

被引：26

作者：

BAKIOGLU, I

HATTORI, Y

KUTLAR, A

MATHEW, C

HUISMAN, THJ

机构：

[1] MED COLL GEORGIA, CTR COMPREHENS SICKLE CELL, DEPT CELL & MOLEC BIOL, AUGUSTA, GA 30912 USA

[2] UNIV STELLENBOSCH, SCH MED, MRC, MOLEC & CELLULAR CARDIOL UNIT, TYGERBERG 7505, SOUTH AFRICA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1985年 / 20卷 / 03期

关键词：

D O I：

10.1002/ajh.2830200313

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Five adult SS patients from Qatar, Turkey, and South Africa with mild disease, had greatly elevated Hb F and specific patterns of polymorphic sites on their .beta.s chromosomes. One subject had an .alpha.-thalassemia (-.alpha./-.alpha.). The haplotypes were the common type # 19, associated with severe disease, and type # 31, not seen thus far in an SS patient (numbering system of Antonarakis et al [2]). The data suggest that modifications in the DNA of the .beta.s # 31 chromosome promotes the synthesis of .gamma. chains.

引用

页码：297 / 300

页数：4

共 10 条

[1] ORIGIN OF THE BETA-S-GLOBIN GENE IN BLACKS - THE CONTRIBUTION OF RECURRENT MUTATION OR GENE CONVERSION OR BOTH
ANTONARAKIS, SE
BOEHM, CD
SERJEANT, GR
THEISEN, CE
DOVER, GJ
KAZAZIAN, HH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (03): : 853 - 856
[2] ORGANIZATION OF ALPHA-CHAIN GENES AMONG HB G-PHILADELPHIA HETEROZYGOTES IN ASSOCIATION WITH HB S, BETA-THALASSEMIA, AND ALPHA-THALASSEMIA-2
FELICE, AE
OZDONMEZ, R
HEADLEE, ME
HUISMAN, THJ
[J]. BIOCHEMICAL GENETICS, 1982, 20 (7-8) : 689 - 701
[3] DUTCH BETA-0-THALASSAEMIA - A 10 KILOBASE DNA DELETION ASSOCIATED WITH SIGNIFICANT GAMMA-CHAIN PRODUCTION
GILMAN, JG
HUISMAN, THJ
ABELS, J
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1984, 56 (02) : 339 - 348
[4] Gilman JG, BLOOD
[5] Huisman TH, 1977, HEMOGLOBINOPATHIES T
[6] HUISMAN THJ, 1981, ADV HEMOGLOBIN ANAL, P23
[7] MILD CLINICAL COURSE IN 2 SOUTH-AFRICAN CASES OF SICKLE-CELL-ANEMIA
MATHEW, C
RUBENSTEIN, R
JACOBS, P
[J]. ACTA HAEMATOLOGICA, 1984, 71 (04) : 247 - 250
[8] LACK OF INFLUENCE OF FETAL HEMOGLOBIN LEVELS OR ERYTHROCYTE INDEXES ON THE SEVERITY OF SICKLE-CELL-ANEMIA
POWARS, DR
SCHROEDER, WA
WEISS, JN
CHAN, LS
AZEN, SP
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1980, 65 (03) : 732 - 740
[9] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATION OF GLOBIN CHAINS ON A LARGE-PORE C-4 COLUMN
SHELTON, JB
SHELTON, JR
SCHROEDER, WA
[J]. JOURNAL OF LIQUID CHROMATOGRAPHY, 1984, 7 (10): : 1969 - 1977
[10] WILSON JB, 1983, J LAB CLIN MED, V102, P174

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