ABNORMALITIES OF ASCORBIC-ACID METABOLISM AND DIABETIC CONTROL - DIFFERENCES BETWEEN DIABETIC-PATIENTS AND DIABETIC RATS

被引:31
作者
YUE, DK [1 ]
MCLENNAN, S [1 ]
MCGILL, M [1 ]
FISHER, E [1 ]
HEFFERNAN, S [1 ]
CAPOGRECO, C [1 ]
TURTLE, JR [1 ]
机构
[1] ROYAL PRINCE ALFRED HOSP,CTR DIABET,SYDNEY,NSW,AUSTRALIA
关键词
Ascorbic acid; Collagen; Diabetic complication; Free radical; Glycosylated haemoglobin; Vitamin;
D O I
10.1016/0168-8227(90)90051-T
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Ascorbic acid is required in the synthesis of collagen and is also an important anti-oxidant. In a previous study, plasma ascorbic acid concentration was found to be decreased in diabetic patients but there was no relationship with blood glucose level. In the current study of diabetic patients, both plasma ascorbic acid and its urinary excretion correlated inversely with glycosylated hemoglobin level. Plasma ascorbic acid was also lower in diabetic rats but urinary ascorbic acid was elevated. The divergent trend in urinary ascorbic acid excretion observed in diabetic patients and diabetic rats may be due to difference in the ability of these two species to synthesize ascorbic acid. Difference in renal reabsorption of ascorbic acid may also be a relevant factor. The lower plasma and urinary ascorbic acid levels in diabetic patients with more severe hyperglycaemia indicates that this group of patients is particularly at risk of developing deficiency of this vitamin. As ascorbic acid has many important functions in the body, it may be necessary to supplement this vitamin in patients with chronically poorly controlled diabetes. © 1990.
引用
收藏
页码:239 / 244
页数:6
相关论文
共 22 条
[1]  
BARNES MJ, 1976, ANN NY ACAD SCI, V258, P264
[2]   FREE-RADICALS IN BIOLOGICAL-SYSTEMS - A REVIEW ORIENTATED TO INFLAMMATORY PROCESSES [J].
BLAKE, DR ;
ALLEN, RE ;
LUNEC, J .
BRITISH MEDICAL BULLETIN, 1987, 43 (02) :371-385
[3]   ESTIMATION OF DEHYDROASCORBIC ACID IN BLOOD OF DIABETIC-PATIENTS [J].
CHATTERJEE, IB ;
BANERJEE, A .
ANALYTICAL BIOCHEMISTRY, 1979, 98 (02) :368-374
[4]   HYPERGLYCEMIA-INDUCED INTRACELLULAR DEPLETION OF ASCORBIC-ACID IN HUMAN MONONUCLEAR LEUKOCYTES [J].
CHEN, MS ;
HUTCHINSON, ML ;
PECORARO, RE ;
LEE, WYL ;
LABBE, RF .
DIABETES, 1983, 32 (11) :1078-1081
[5]  
KELLNER A, 1979, AM J CLIN NUTR, V32, P530
[6]  
LEVINE M, 1986, NEW ENGL J MED, V314, P892, DOI 10.1056/NEJM198604033141407
[7]  
LOVEN DP, 1985, SUPEROXIDE DISMUTASE, V3, P151
[8]   DEFICIENCY OF ASCORBIC-ACID IN EXPERIMENTAL DIABETES - RELATIONSHIP WITH COLLAGEN AND POLYOL PATHWAY ABNORMALITIES [J].
MCLENNAN, S ;
YUE, DK ;
FISHER, E ;
CAPOGRECO, C ;
HEFFERNAN, S ;
ROSS, GR ;
TURTLE, JR .
DIABETES, 1988, 37 (03) :359-361
[9]   EFFECT OF DEHYDROASCORBIC ACID ON ISLETS OF LANGERHANS OF RAT PANCREAS [J].
MERLINI, D ;
CARAMIA, F .
JOURNAL OF CELL BIOLOGY, 1965, 26 (01) :245-&
[10]  
MOORADIAN AD, 1986, AM J CLIN NUTR, V45, P877