5-HYDROXYTRYPTAMINE MODULATES SPIKE FREQUENCY REGULATION IN RETICULOSPINAL NEURONS INVOLVED IN THE CONTROL OF LOCOMOTION IN LAMPREY

被引：15

作者：

DIPRISCO, GV ^{[1
]}

DUBUC, R ^{[1
]}

WALLEN, P ^{[1
]}

GRILLNER, S ^{[1
]}

机构：

[1] KAROLINSKA INST,NOBEL INST NEUROPHYSIOL,BOX 60400,S-10401 STOCKHOLM 60,SWEDEN

来源：

NEUROSCIENCE LETTERS | 1992年 / 134卷 / 02期

关键词：

5-HYDROXYTRYPTAMINE; RETICULOSPINAL NEURON; AFTERHYPERPOLARIZATION; CA2+-ACTIVATED K+ CHANNEL; INTRACELLULAR RECORDING; LOCOMOTION; LAMPREY;

D O I：

10.1016/0304-3940(92)90535-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate the effects of 5-hydroxytryptamine (5-HT) on reticulospinal neurons involved in the initiation and control of locomotion in lamprey, 5-HT (10 mM) was locally pressure ejected on the dorsal surface of the brainstem during intracellular recordings from identified reticulospinal neurons in the in vitro brainstem-spinal cord preparation. 5-HT induced a reduction of the late afterhyperpolarization (AHP) following the spike due to a reduction of a Ca2+-activated K+ current. In addition, 5-HT caused a resting membrane hyperpolarization in a proportion of these cells. Due to the 5-HT induced reduction of the AHP, reticulospinal cells, including those that became hyperpolarized by an application of 5-HT, discharged at a higher rate after 5-HT as a response to the same excitatory drive.

引用

页码：279 / 283

页数：5

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